As a result of their heterotrophic digestion, people are reliant upon food, which shows the interest in food poisonousness. Present day organic chemistry, atomic and cell science, software engineering, bioinformatics, and high-throughput and high-satisfied screening techniques have made it conceivable to characterize expected poisons in food and track down unfortunate results. The components of poison activities are perplexing, yet numerous harmful impacts bring about oxidative pressure and constant aggravation, which speed up maturing and cause degenerative sicknesses and cell demise. The advancement of option, profoundly predicable in silico models has been made conceivable by the combination of food harmfulness information accumulated all through biochemical and cell-situated in vitro, creature in vivo, and human clinical settings. These frameworks utilize a blend of modern PC based calculations and in vitro cellbased models. An expansion in the utilization of these yet in addition elective lower pecking order substitute creature models (for example Drosophila melanogaster; Caenorhabditis elegans or Danio rerio) and endeavors to coordinate organotypic frameworks and undifferentiated cell based measures have come about because of a reduction in rat creature testing, which has restrictions like significant expenses, low throughput readouts, conflicting reactions, moral issues, and worries about extra probability to susceptible people. Notwithstanding these victories, there are as yet numerous impediments in the different fields of food harmfulness.