The aim of the study was to research adrenoreceptors sensitivity and microvascular diameter changes in several severity of crush syndrome.Experiments were administered on 50 white rats (200- 250 gr) with the utilization of crush syndrome modeling classical methods in various periods of compression (3 hours, 6 hours) and decompression (1 hour, 6 hours). Microhemocirculation and microvascular adrenoreactivity were studied in rats’ intestine mesenteric arterioles by biomicroscope “Nikkon Labopot”. Microvascular adrenoreactivity was studied by pharmacological analysis, concretely, with the utilization of epinephrine on the idea of α- or β- adrenal receptors blockers action.Numerous microhemocirculatory disturbances were revealed in mesenteric arterioles It is evident due to following changes in microhemocirculation: microvessels diameter changes, adrenoreactive structures dysfunction. Crush syndrome causes suppression of adrenoceptor sensitivity of mesenteric arterioles towards adrenaline which may be explained by stress induced hypercatecholaminemia, which is extremely apparent in decompression period. Vascular tone practically remains without adrenal control, which negatively affects the regional blood flow to the organs We can assume that severity of the changes correlates with compression and immensely on decompression period duration.
