Perinatal transmission of HIV has significantly diminished in big league salary nations over the most recent couple of years with current rates underneath 1%, yet it actually happens in high-hazard circumstances, primarily pregnant ladies with late determination of disease, poor antiretroviral adherence and a high popular burden (VL). In these high-hazard circumstances, numerous suppliers suggest consolidated neonatal prophylaxis (CNP). Our point was to assess the wellbeing and poisonousness of CNP in babies considered at high-hazard of HIV disease among mother-newborn child sets in the Madrid Cohort.