Complex Lymphatic Anomalies (CLA) are idiopathic abnormalities of the lymphatic system that also affect the soft tissues of the bones. Different CLA subtypes have varying degrees of aberrant lymphatic presentation and boney invasion. Due to these diseases' rarity and unpredictable course, the aetiology has proven to be very elusive. We gathered research on the four main CLA subtypes and
discussed each one's clinical presentation, lymphatic invasion, osseous profile, and regulatory pathways connected to aberrant bone loss brought on by the lymphatic invasion in this review. We emphasise crucial proliferation and differentiation mechanisms that are shared by lymphatics and bone, as well as potential interactions between these systems that could promote lymphangiogenesis and result in bone loss.
