Idiopathic pulmonary fibrosis (IPF) is an irreversible lung condition marked by progressive scarring that impairs gas exchange, causes alveolar stiffness, and reduces lung capacity. After receiving an IPF diagnosis, we sought to find genetic variations linked to deteriorating lung function or decreased gas transport. We performed a genome-wide meta-analysis of longitudinal measurements of forced vital capacity (FVC) and lung carbon monoxide diffusing capacity (DLCO) in people with IPF. In a separate, independent investigation, suggestively significant variations were looked through in more detail. According to the standards of the European Respiratory Society and American Thoracic Society, cases were diagnosed in all four investigations. When all discovery and follow-up studies were considered in the meta-analysis, a variation was considered to be significantly associated if it had a meta-analysis.
