Kaposi Sarcoma (KS) is a locally aggressive angioproliferative tumour with varied histological characteristics at different stages. Histopathological findings have diagnostic relevance depending on the stage, frequency, and kind of abnormalities reported. The study’s goal was to establish a finding or a combination of results that are prevalent in different phases of KS and can successfully identify that stage.
The Human Herpesvirus 8 (HHV-8) virus, a member of the gammaherpesvirus subfamily, is involved in the development of Kaposi Sarcoma (KS). Moritz Kaposi, a Hungarian dermatologist, was the first to characterize it as a “idiopathic numerous pigmented sarcoma of the skin” in 1872. KS is a locally aggressive tumour with a low malignancy potential that progresses through patch, plaque and nodular phases. Significant histological characteristics are predominant at each stage, posing different problems in histopathological diagnosis and differential diagnosis. These diagnostic challenges include benign or reactive lesions in the patch stage, as well as other vascular sarcomas or cutaneous spindle cell tumours in the nodule stage.
