The autonomic nervous system, which consists of the parasympathetic and sympathetic divisions and is carefully regulated at many hierarchical levels, regulates cardiac function. Numerous inherited and non-hereditary conditions of the Central Nervous System (CNS) can have an impact on the heart directly or indirectly (brain-heart disorders). Epilepsy, stroke, subarachnoid hemorrhage, bacterial meningitis, and head injuries are the most well-known CNS illnesses. Additionally, several hereditary and cardiac functioning may be hampered by non-heritable neurodegenerative diseases. Arrhythmias, cardiomyopathy, or autonomic dysfunction are all signs of cardiac disease. Heart failure, systolic or diastolic dysfunction, myocardial infarction, arterial hypertension, or pulmonary hypertensions are some of the less common cardiac consequences of CNS diseases. Takotsubo syndrome, which is a form of stress induced cardiac dysfunction, is the most common cardiomyopathy caused by genetic CNS disease (TTS). While the insular cortex, amygdala, and hypothalamus are all involved in the complicated regulation occurring in the central nervous system, the intracardiac nervous system is also responsible for the local cardiac regulation occurring within the heart. The intra-cardiac neural system's current knowledge is reviewed in this article and recognized its part in the pathogenesis of cardiovascular disorders
