Health care sciences and psychology are both interested in the topic of Health-Related Quality of Life (HRQoL). It is essential to gain a deeper understanding of the internal mechanisms underlying this effect using large samples in order to better comprehend HRQoL and formulate focused recommendations to enhance HRQoL. The goal of the current study is to examine how interpersonal trust, seen from a developmental lens, mediates the relationship between age and HRQoL. This study's objectives were to profile the Pediatric Quality of Life Inventory 4.0 generic scale in China, assess the association between age and health-related quality of life, and examine the mediating and moderating effects of gender and interpersonal trust. Measures of demographics, health-related quality of life, and interpersonal trust were completed by a sample of 6248 kids. The mediating function of interpersonal trust and the moderating role of gender were tested using regression analysis. Age was linked to reduced interpersonal trust and health-related quality of life. Similar gender differences were seen, with boys expressing lower interpersonal trust and higher health-related quality of life than girls. In addition, as they aged, girls' health-related quality of life decreased more than that of boys. Age could be predicted by a lower level of interpersonal trust, according to regression studies, which could lead to a lower health-related quality of life. Additionally, the gender difference in the mediation effect was attenuated, with boys experiencing a larger mediation impact than girls. The current study confirms age and gender differences in interpersonal trust and health-related quality of life.
